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Desensitisation ‘Desensitisation’ of the immune system, is a new method that has the potential to save many lives and could mean a crucial difference between receiving a transplant and spending the rest of one’s life on dialysis Doctors successfully altered patients’ immune systems to allow them to accept kidneys from incompatible donors. The process Desensitisation involves first filtering the antibodies out of a patient’s blood. The patient is then given an infusion of other antibodies to provide some protection while the immune system regenerates its own antibodies. For some reason — exactly why is not known — the person’s regenerated antibodies are less likely to attack the new organ. But if the person’s regenerated natural antibodies are still a concern, the patient is treated with drugs that destroy any white blood cells that might make antibodies that would attack the new kidney. Other possibilities Although by far the biggest use of desensitisation would be for kidney transplants, the process might be suitable for living donor transplants of livers and lungs, researchers said. The liver is less sensitive to antibodies so there is less need for desensitization. The desensitisation procedure takes time — for some patients as long as two weeks — and is performed before the transplant operation, so patients must have a living donor.
By: Vishal ProfileResourcesReport error
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